A study of chemical carcinogenesis: Comparative carcinogenicity of 5-methylchrysene, benzo(a)pyrene, and modified chrysenes
1975; Elsevier BV; Volume: 1; Linguagem: Inglês
10.1016/s0304-3835(75)96166-2
ISSN1872-7980
AutoresStephen S. Hecht, Myrna Loy, Robert R. Maronpot, Dietrich Hoffmann,
Tópico(s)Synthesis and Biological Evaluation
ResumoThe carcinogenic activity of 5-methylchrysene (5-MeC) was assayed in the connective tissue of C-57 black mice, and 5-MeC was compared to benzo(a)pyrene (BaP) and certain modified chrysene derivatives for tumorigenic activity on mouse skin. Subcutaneous injections of 5-MeC (total dose, 0.5 mg) resulted in 22 sarcoma-bearing animals in a group of 25. On mouse skin, 5-MeC and BaP had comparable complete carcinogenic activity, and 5-MeC was a stronger tumor initiator than BaP. Compared to 5-MeC, 12-fluoro-5-methylchrysene was a weaker tumor initiator on mouse skin, while 5-methoxychrysene was somewhat less active. 1-Fluoro-4-methylchrysene and 6-methoxy-5-methylchrysene lacked significant tumor-initiating activity. The bioassay data are discussed in respect to the steric and electronic features of the chrysene ring system.
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