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Relationship of olfactory function with olfactory bulbus volume, disease duration and Unified Parkinson’s disease rating scale scores in patients with early stage of idiopathic Parkinson’s disease

2013; Elsevier BV; Volume: 20; Issue: 10 Linguagem: Inglês

10.1016/j.jocn.2012.11.017

1532-2653

Hüsniye Aylin Hakyemez, Bayram Veyseller, Feriha Özer, Serkan Özben, Gülüm İvgin Bayraktar, Defne Gürbüz, Sibel Çetin, Yavuz Selim Yıldırım,

Essential Oils and Antimicrobial Activity

We aimed to investigate the relationship between olfactory function and olfactory bulbus (OB) volume, disease duration and Unified Parkinson's disease rating scale (UPDRS) scores in early stage idiopathic Parkinson's disease patients. The University of Pennsylvania Smell Identification Test (UPSIT) was used for the evaluation of olfactory function. UPSIT scores for patients with Parkinson's disease were significantly lower than controls. There was no significant difference between stage 1 and stage 2 patients. OB volumes were higher in stage 1 and 2 patients than controls, but there was no statistical difference between the three groups. No significant correlation was found between UPSIT and UPDRS total scores, nor between UPSIT scores and disease duration in stage 1 and 2 patients. According to our results, we propose UPSIT be used as a screening test to diagnose presymptomatic patients, but not OB volumes.