Obesity following disturbance of the ventromedial hypothalamus: A comparison of lesions, lateral cuts, and anterior cuts
1971; Elsevier BV; Volume: 7; Issue: 2 Linguagem: Inglês
10.1016/0031-9384(71)90273-3
ISSN1873-507X
AutoresD.J. Albert, Leonard H Storlien, J Albert, C.J. Mah,
Tópico(s)Regulation of Appetite and Obesity
ResumoThe effect of ventromedial hypothalamic (VMH) lesions, cuts lateral to the VMH, and cuts anterior to the VMH were compared in male and female rats. The rate of weight gain following complete lesions in the region of the VMH is higher than normal but similar for males and females. Cuts lateral to the VMH cause increased weight gains in both males and females, but the effect is less than that following lesions. Cuts anterior to the VMH also give an increased weight gain but only in female rats. These results indicate that about 70 per cent of the increased weight gain following VMH removal is accounted for by the interruption of pathways passing through the anterior and lateral borders of this region. The results are discussed in terms of a disturbance of the interaction of excitatory and inhibitory systems with lateral cuts, and a disturbance of female hormones with anterior cuts.
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