Differences in CCR5 expression on peripheral blood CD4+CD28− T-cells and in granulomatous lesions between localized and generalized Wegener’s granulomatosis
2003; Elsevier BV; Volume: 108; Issue: 1 Linguagem: Inglês
10.1016/s1521-6616(03)00121-9
ISSN1521-7035
AutoresPeter Lamprecht, Hilke Brühl, Erdmann Anika, Konstanze Holl‐Ulrich, Elena Csernok, Ulrike Seitzer, Matthias Mack, Alfred C. Feller, E. Reinhold‐Keller, Wolfgang L. Gross, Antje Müller,
Tópico(s)Otitis Media and Relapsing Polychondritis
ResumoWegener's granulomatosis (WG) is an autoimmune disease characterized by granulomatous lesions and a necrotizing vasculitis. Th1-type-cells lacking CD28 are expanded independent of age and immunosuppressive therapy in WG. To address their migratory properties of CD4+CD28− T-cells we studied the expression of the inducible inflammatory Th1-type chemokine receptor CCR5 in localized WG and generalized WG. Expansion of CD4+CD28− T-cells was more prominent in generalized WG compared to localized WG. In localized WG a larger fraction of CD4+CD28− T-cells displayed CCR5 expression compared to generalized WG. CCR5 expression was also higher in granulomatous lesions in localized WG. Higher levels of CCR5 expression on CD4+CD28− T-cells in localized WG may favor stronger CCR5-mediated recruitment of this T-cell subset into granulomatous lesions in localized WG. Expansion of Th-1-type CD4+CD28−CCR5+ effector memory T-cells might contribute to disease progression and autoreactivity, either directly, by maintaining the inflammatory response, or as a result of bystander activation.
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