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Role of anti-inflammatory adipokines in obesity-related diseases

2014; Elsevier BV; Volume: 25; Issue: 7 Linguagem: Inglês

10.1016/j.tem.2014.03.009

1879-3061

Koji Ohashi, Rei Shibata, Toyoaki Murohara, Noriyuki Ouchi,

Lipid metabolism and disorders

Obesity results in many health complications. Accumulating evidence indicates that the obese state is characterized by chronic low-grade inflammation, thereby leading to the initiation and progression of obesity-related disorders such as type 2 diabetes, hypertension, cardiovascular disease, and atherosclerosis. Fat tissue releases numerous bioactive molecules, called adipokines, which affect whole-body homeostasis. Most adipokines are proinflammatory, whereas a small number of anti-inflammatory adipokines including adiponectin exert beneficial actions on obese complications. The dysregulated production of adipokines seen in obesity is linked to the pathogenesis of various disease processes. In this review we focus on the role of the anti-inflammatory adipokines that are of current interest in the setting of obesity-linked metabolic and cardiovascular diseases.