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Effects of volatile anaesthetic agents on eeg activity recorded in limbic and sensory systems

1972; Springer Nature; Volume: 19; Issue: 3 Linguagem: Inglês

10.1007/bf03028292

0008-2856

R. Julien, Eva M. Kavan, Henry W. Elliott,

Veterinary Pharmacology and Anesthesia

As part of a systematic study of the effects of anaesthetic agents on cortical and subcortical activity of experimental animals, diethyl ether, halothane, methoxy-flurane, and enflurane (Ethrane) were administered to cats with chronically-implanted electrodes sterotaxically placed in selected nuclei of the sensory system (centrum medianum, ventralis posterior lateralus, and mesencephalic reticular formation) and in representative areas of the limbic system (pes hipoccampi and nucleus amygdalae). Skull electrodes were placed over frontal, parietal and/or temporal cortex. Following induction, an anaesthetic state was maintained for at least 30 minutes and deeper levels of anaesthesia were avoided. Minimal electrographic changes were observed with ether. Spiking, particularly on the limbic system, was observed with the 3 halogenated compounds. These changes were most pronounced with enflurane.