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Predisposition to Renal Cell Carcinoma Due to Alteration of a Cancer Susceptibility Gene

1992; American Association for the Advancement of Science; Volume: 255; Issue: 5052 Linguagem: Inglês

10.1126/science.1553556

1095-9203

Cheryl L. Walker, Thomas L. Goldsworthy, Douglas C. Wolf, Jeffrey I. Everitt,

Cancer Genomics and Diagnostics

A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.