Prevention of hypoxia-induced transient amnesia by post-hypoxic hyperoxia
1982; Elsevier BV; Volume: 29; Issue: 6 Linguagem: Inglês
10.1016/0031-9384(82)90299-2
ISSN1873-507X
Autores Tópico(s)Zebrafish Biomedical Research Applications
ResumoAbstract Rats subjected to hypoxia (2% O2 in N2) for 30 sec following training in an active avoidance task subsequently show a transient medium-term memory (MTM) amnesia for that task. The occurrence of this transient post-hypoxic amnesia may be prevented by treating the animals with hyperoxia (100% O2 for 2 min) providing this is done within 1.5 min following the hypoxia. In view of the rapid recovery of normal brain function in air following hypoxia, the ability of hyperoxia to reenable MTM formation even if it is given 1.5 min after hypoxia suggests the existence of a “very short term trace” which normally gives rise to medium term memory. These results are incorporated into a four phase model of memory consolidation.
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