Landau—Kleffner syndrome
1995; Oxford University Press; Volume: 118; Issue: 6 Linguagem: Inglês
10.1093/brain/118.6.1529
ISSN1460-2156
AutoresFrank Morrell, Walter W. Whisler, Michael C. Smith, Thomas J. Hoeppner, Leyla de Toledo‐Morrell, Serge Pierre‐Louis, Andrés M. Kanner, Janice M. Buclow, R. Ristanovic, Donna Bergen, Michael Chez, Hisanori Hasegawa,
Tópico(s)EEG and Brain-Computer Interfaces
ResumoLandau—Kleffner syndrome (LKS) is an acquired epileptic aphasia occurring in childhood and associated with a generally poor prognosis for recovery of speech. It is thought to be the result of an epileptogenic lesion arising in speech cortex during a critical period of development. Utilizing a new surgical technique designed to eliminate the capacity of cortical tissue to generate seizures while preserving the normal cortical physiological function, we have treated 14 children with aphasia, seizures and a severely abnormal EEG by multiple subpial transection of the epileptogenic cortex. Seven of the 14 patients (50%) have recovered age-appropriate speech, are in regular classes in school and no longer require speech therapy. Four of the 14 (29%) have shown marked improvement, are speaking and understanding verbal instruction but are still receiving speech therapy. Thus, 11 of the 14(79%), none of whom had used language to communicate for at least 2 years, are now speaking—a rate of sustained improvement considered unusual in this disorder. This study documents the value of a treatment modality not previously used in LKS. Success depends on selection of cases having severe epileptogenic abnormality that can be demonstrated to be unilateral in origin despite a bilateral electrographic manifestation
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