Portal de Periódicos da CAPES

Highly stereoselective synthesis of exocyclic alkenes via cyclialkylation

1987; Elsevier BV; Volume: 28; Issue: 47 Linguagem: Inglês

10.1016/s0040-4039(01)81055-8

1873-3581

Ei‐ichi Negishi, Yantao Zhang, V. BAGHERI,

Catalytic C–H Functionalization Methods

Treatment of stereodefined ω-halo-2-iodoalkene derivatives (1), prepared via stereoselective addition reactions of alkynes, with either n-BuLi (1 equiv) or t-BuLi (2 equiv) can produce exocyclic alkenes whose isomeric purity is essentially 100%.