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A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and Hepatitis

1967; American College of Physicians; Volume: 66; Issue: 5 Linguagem: Inglês

10.7326/0003-4819-66-5-924

1539-3704

Baruch S. Blumberg,

RNA modifications and cancer

Article1 May 1967A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and HepatitisBARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P., BETTY JANE S. GERSTLEY, M.D., DAVID A. HUNGERFORD, PH.D., W. THOMAS LONDON, M.D., ALTON I. SUTNICK, M.D., F.A.C.P.BARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P., BETTY JANE S. GERSTLEY, M.D., DAVID A. HUNGERFORD, PH.D., W. THOMAS LONDON, M.D., ALTON I. SUTNICK, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-924 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWe have previously reported the presence of an isoantigen of human sera, rare or absent in normal U. S. and northern European populations but relatively common in patients with leukemia (1, 2). The "new" isoantigen has been called "Australia antigen" because it was first found in the serum of an Australian aborigine. It appears to be different from the low-density lipoprotein isoantigen system first described in our laboratory (3-5). Hemophilia patients and others who have received multiple transfusions may develop precipitating isoantibodies against Australia antigen. These precipitating isoantibodies react with a protein in the blood of some normal and some...References1. BLUMBERG BS: Polymorphism of serum proteins and the development of iso-precipitins in transfused patients. Bull. N. Y. Acad. Med. 40: 377, 1964. MedlineGoogle Scholar2. BLUMBERGALTERVISNICH BSHJS: A "new" antigen in leukemia sera. JAMA 191: 541, 1965. CrossrefMedlineGoogle Scholar3. ALLISONBLUMBERG ACBS: An isoprecipitin reaction distinguishing human serum-protein types. Lancet 1: 634, 1961. CrossrefMedlineGoogle Scholar4. BLUMBERGALLISON BSAC: Studies on the isoprecipitin-determined human serum polymorphism, in Proceedings of the International Congress on Human Genetics, 2nd (Rome). 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STOLLERCOLLMAN ARD: Incidence of infectious hepatitis followed by Down's syndrome nine months later. Lancet 2: 1221, 1965. CrossrefMedlineGoogle Scholar25. MELLALANG BDJ: Leucocyte mitosis: suppression in vitro associated with acute infectious hepatitis. Science 155: 80, 1967. CrossrefMedlineGoogle Scholar26. FAILKOWUCHIDAHECHTMOTULSKY PJIFAG: Increased frequency of thyroid auto-antibodies in mothers of patients with Down's syndrome. Lancet 2: 868, 1965. CrossrefMedlineGoogle Scholar27. ROBINSONPUCK ATT: Sex chromatin in newborns; presumptive evidence for external factors in human nondisjunctions. Science 148: 83, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BARUCH S. BLUMBERG, M.D., D.PHIL., F.A.C.P.; BETTY JANE S. GERSTLEY, M.D.; DAVID A. HUNGERFORD, PH.D.; W. THOMAS LONDON, M.D.; ALTON I. SUTNICK, M.D., F.A.C.P.Affiliations: Philadelphia, PennsylvaniaFrom the Institute for Cancer Research, Fox Chase, Philadelphia, Pa.This study was supported by research grants CA-06551, CA-08069, and FR-05539, the National Cancer Institute, the National Institutes of Health, Bethesda, Md.Requests for reprints should be addressed to Baruch S. Blumberg, M.D., The Institute for Cancer Research, 7701 Burholme Ave., Fox Chase, Philadelphia, Pa. 19111. 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TO ACUTE AND CHRONIC LIVER INJURYGLOMERULONEPHRITIS WITH DEPOSITION OF AUSTRALIA ANTIGEN-ANTIBODY COMPLEXES IN GLOMERULAR BASEMENT MEMBRANEErgasteric Hepatitis: Endemic Hepatitis Associated with Australia Antigen in a Research LaboratoryALTON I. SUTNICK, M.D., F.A.C.P., W. THOMAS LONDON, M.D., F.A.C.P., IRVING MILLMAN, Ph.D., BETTY JANE S. GERSTLEY, M.D., F.A.C.P., BARUCH S. BLUMBERG, M.D., Ph.D., F.A.C.P.FREQUENCY OF AUSTRALIA ANTIGEN IN PATIENTS WITH LEUKÆMIA IN DIFFERENT COUNTRIESAustralia Antigen: Large-Scale Purification from Human Serum and Biochemical Studies of Its ProteinsTHE INCIDENCE OF AUSTRALIA ANTIGEN IN BLOOD DONORS AND IN CERTAIN HIGH–RISK PATIENT POPULATIONSSensitive Matrix Gel Diffusion Test for the Detection of Australia AntigenSpecific Antibody Response after Transfusion of Australia Antigen-Positive Blood in a Patient with Liver CirrhosisOCCURRENCE OF AUSTRALIA ANTIGEN IN PATIENTS WITH DOWN'S SYNDROME IN POLAND*A Simple Method for Preparation of Anti-Australia Antigen SerumAustralia Antigen in Liver Disease [ Abridged ]Familial Hepatoma with Hepatitis-Associated AntigenEDWARD K. DENISON, M.D., ROBERT L. PETERS, M.D., TELFER B. REYNOLDS, M.D., F.A.C.P.Diagnostic VirologyThe Australia (hepatitis-associated) antigen in fibrinogen and other fractions of human plasmaNeue Gesichtspunkte bei der Verhütung der transfusionsbedingten Serumhepatitis (Au/SH-Antigen)Reactions of Viruses in Agar GelTHE AUSTRALIA ANTIGEN IN AUTO-IMMUNE LIVER DISEASEL'antigène Australia mise en évidence, spécificité, intérêt pratiqueRNA of Australia AntigenAustralia Antigen and Hepatitis: A Comprehensive ReviewLepromatous leprosy and australia antigen with comments on the genetics of leprosyDISTINCTIONS IN CHRONIC ACTIVE HEPATITIS BASED ON CIRCULATING HEPATITIS-ASSOCIATED ANTIGENHEPATITIS-ASSOCIATED ANTIGEN AND CIRRHOSIS IN UGANDAFrequency of the Australia-SH Antigen and Antibody among Norwegian Blood DonorsAUSTRALIA ANTIGEN IN PATIENTS WITH VARIOUS LIVER DISEASESDetection of Serum Hepatitis Virus Carriers by Testing for the SH (Australia) AntigenCo-occurrence of anti-Ag and anti-Australia Antibodies in Transfused PatientsAustralia antigen and primary liver cancerHepatitis-associated antigenLEVODOPA AND MIGRAINEAUSTRALIA (HEPATITIS) ANTIGEN IN SARCOIDOSISA "VIRUS" ASSOCIATED WITH SERUM HEPATITISStudies in Down's SyndromeA Conceptual Basis of Viral HepatitisExperiences on Australia Antigen in ItalyHEPATITIS-ASSOCIATED ANTIGEN IN UGANDAN PATIENTS WITH HEPATOCELLULAR CARCINOMAAUSTRALIA ANTIGEN, HEPATITIS VIRUS AND DOWNS SYNDROMEHepatitisAUSTRALIA ANTIGEN AND VIRAL HEPATITIS IN SYDNEY: A HOSPITAL SERIESAustralia Antigen and HepatitisDIFFERENT AUSTRALIA-ANTIGEN DETERMINANTS IN ACUTE VIRAL HEPATITISSERUM HEPATITIS AND THE AUSTRALIA ANTIGENPrecipitating factors against chicken proteins in patients with Down's syndromeAN ANTIGEN CLOSELY RELATED TO THE AUSTRALIA-SH ANTIGEN IN THE SERUM OF AN APPARENTLY HEALTHY BLOOD DONORAustralia Antigen in a Closed Adult Population Monitored for Serum Glutamic Oxalacetic TransaminaseAn Unusual Form of Diabetes Mellitus in Ataxia TelangiectasiaPreoperative Preparation of the Jaundiced Patient: A Review of Current PracticePLASMA, ERYTHROCYTE AND LEUCOCYTE ZINC LEVELS IN DOWN'S SYNDROMEAntibody Responses to the Epstein–Barr Virus and Cytomegaloviruses after Open-Heart and Other SurgeryViral Hepatitis: Revised Concepts as a Result of the Study of Australia AntigenTHE AUSTRALIA ANTIGEN AND VIRAL HEPATITISImmunologic Distinction between Infectious and Serum HepatitisAustralia Antigen, Transfusion and HepatitisAdaptation to infectious disease. Australia antigen and hepatitisViral HepatitisCELLULAR LOCALISATION OF AUSTRALIA ANTIGEN IN THE LIVER OF PATIENTS WITH LYMPHOPROLIFERATIVE DISORDERSFailure to detect an Antigen associated with Hepatitis in a Community EpidemicProgress report: hepatitis-associated (Australia) antigen.The Australia antigen in Brazilian healthy persons and in leprosy and leukaemia patientsViral HepatitisN. RAPHAEL SHULMAN, M.D., RICHARD J. HIRSCHMAN, M.D., LEWELLYS F. BARKER, M.D.Australia antigen as a hepatitis virusAustralia (Hepatitis-Associated) Antigen: Physicochemical And Immunological CharacteristicsGenesis of HepatitisThe Geographical Pathology of Liver Disease in ManBiophysical Properties of Australia AntigenTelevision scanning of cervical smears: the quantimet.Laboratory tests in viral hepatitis.An Epidemic of Hepatitis in a Chronic-Hemodialysis UnitHepatitis VirusAUSTRALIA ANTIGEN IN CHRONIC ACTIVE LIVER DISEASE WITH CIRRHOSISViral Hepatitis and the Australia-SH AntigenAUSTRALIA ANTIGEN IN ACUTE AND CHRONIC LIVER DISEASES.H. ANTIGEN IN HÆMODIALYSIS-ASSOCIATED HEPATITISAustralia Antigen and HepatitisPersistence of the Serum Hepatitis (SH-Australia) Antigen for Many YearsPRESENCE AND PERSISTENCE OF AUSTRALIAN ANTIGEN IN A SWEDISH HEPATITIS SERIESHEPATITIS ANTIGENAustralia Antigen detected in the Nuclei of Liver Cells of Patients with Viral Hepatitis by the Fluorescent Antibody TechniqueRelation between SH and Australia AntigensAustralia antigen and the quest for a hepatitis virusViral hepatitis in subhuman primates and its relationship to human viral hepatitisAntigène et anticorps des hépatites à virusAdditional Specificities of Australia Antigen and the Possible Identification of Hepatitis CarriersAustralia Antigen and Acute Viral HepatitisW. THOMAS LONDON, M.D., F.A.C.P., ALTON I. SUTNICK, M.D., F.A.C.P., BARUCH S. BLUMBERG, M.D., F.A.C.P.Australia-SH AntigenObservations on Australia Antigen in JapaneseWHAT'S IN P.V.C.?RELATION OF AUSTRALIA AND SH ANTIGENSA NEW PRECIPITATING ANTIGEN-ANTIBODY SYSTEM (PENNSYLVANIA ANTIGEN) IN HUMAN SERUMParticles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and HepatitisSERUM-PROTEINS IN DOWN'S SYNDROMEASSOCIATION BETWEEN LEPROMATOUS LEPROSY AND AUSTRALIA ANTIGEN 1 May 1967Volume 66, Issue 5Page: 924-931KeywordsAntigensHemophiliaHepatitis AHepatitis EHepatitis E virusLow density lipoproteinPopulation statisticsProteinsResearch grantsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1967 PDF downloadLoading ...