Portal de Periódicos da CAPES

Anti-inflammatory Benzenoids from Antrodia camphorata

2007; American Chemical Society; Volume: 70; Issue: 6 Linguagem: Inglês

10.1021/np070045e

1520-6025

Jih‐Jung Chen, Wen-Jiou Lin, Chang‐Hui Liao, Po-Chuen Shieh,

Phytochemistry and Bioactivity Studies

Four new compounds, including three new benzenoids, antrocamphin A (1), antrocamphin B (2), and 2,3,4,5-tetramethoxybenzoyl chloride (3), and a new 1,3-dioxolan-2-one derivative, antrodioxolanone (4), together with 13 known compounds have been isolated from the fruiting body of Antrodia camphorata. The structures of these new compounds were determined through spectral analyses including extensive 2D-NMR data. Among the isolates, antrocamphin A (1), antcin A (10), and antcin B (11) exhibited potent inhibition against fMLP-induced superoxide production with IC50 values less than 10 μM.