Hypoxia tolerance in mammalian heterotherms
2004; The Company of Biologists; Volume: 207; Issue: 18 Linguagem: Inglês
10.1242/jeb.01114
ISSN1477-9145
AutoresKelly L. Drew, Michael B. Harris, Joseph C. LaManna, Mark A. Smith, Xiaohui Zhu, Yi L.,
Tópico(s)High Altitude and Hypoxia
ResumoHeterothermic mammals tolerate severe hypoxia, as well as a variety of central nervous system insults, better than homeothermic mammals. Tolerance to hypoxia may stem from adaptations associated with the ability to survive hibernation and periodic arousal thermogenesis. Here, we review evidence and mechanisms of hypoxia tolerance during hibernation, euthermy and arousal in heterothermic mammals and consider potential mechanisms for regenerative-like processes, such as synaptogenesis, observed within hours of hypoxic stress associated with arousal thermogenesis.
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