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Separation and Partial Purification of Plasma-Membrane Fragments from Ehrlich Ascites Carcinoma Microsomes

1965; American Association for the Advancement of Science; Volume: 148; Issue: 3675 Linguagem: Inglês

10.1126/science.148.3675.1343

1095-9203

V.B. Kamat, Donald F. Hoelzl Wallach,

Nanoparticle-Based Drug Delivery

Membrane vesicles arising from the surface of Ehrlich ascites carcinoma cells were separated from the bulk of other microsomal components in Ficoll density gradients. Initial separation depends on the differential action of magnesium ion on various microsomal components. Immunologic and enzymic markers were used to monitor separation and purification steps.