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EFFECTS OF MK-801 ON BLADDER OVERACTIVITY IN RATS WITH CEREBRAL INFARCTION

1998; Lippincott Williams & Wilkins; Volume: 159; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(01)63986-7

1527-3792

Osamu Yokoyama, Yoshiyuki Ishiura, Kazuto Komatsu, Eiko Mita, Yasuo Nakamura, Kazuto Kunimi, Kouji Morikawa, Mikio Namiki,

Anesthesia and Neurotoxicity Research

No AccessJournal of UrologyInvestigative Urology1 Feb 1998EFFECTS OF MK-801 ON BLADDER OVERACTIVITY IN RATS WITH CEREBRAL INFARCTION Osamu Yokoyama, Yoshiyuki Ishiura, Kazuto Komatsu, Eiko Mita, Yasuo Nakamura, Kazuto Kunimi, Kouji Morikawa, and Mikio Namiki Osamu YokoyamaOsamu Yokoyama , Yoshiyuki IshiuraYoshiyuki Ishiura , Kazuto KomatsuKazuto Komatsu , Eiko MitaEiko Mita , Yasuo NakamuraYasuo Nakamura , Kazuto KunimiKazuto Kunimi , Kouji MorikawaKouji Morikawa , and Mikio NamikiMikio Namiki View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)63986-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Our objective was to evaluate the underlying mechanisms of neurogenic voiding dysfunction following cerebral infarction. Materials and Methods: The left middle cerebral artery (MCA) was occluded using 4-0 monofilament nylon thread in male S-D rats. Cystometric examination was performed in unanesthetized and urethane-anesthetized rats through a catheter chronically implanted in the dome of the bladder. Results: Bladder capacity of unanesthetized or urethane anesthetized rats was significantly reduced just after occlusion of the left MCA; 2 weeks after the occlusion, the capacity was less than half that in sham-operated rats. Intravenous administration of N-methyl-d-aspartate (NMDA) receptor antagonist MK-801 to the unanesthetized sham-operated rats led to a marked dose-dependent decrease in bladder capacity. Its administration to unanesthetized rats with cerebral infarction resulted in a slight decrease in bladder capacity. In the urethane-anesthetized state, the bladder capacity of the rats with cerebral infarction was significantly increased by MK-801, 0.1 mg./kg., without inhibiting the contraction pressure or increasing the amount of residual urine. 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Google Scholar Department of Urology, School of Medicine, Kanazawa University, and the Research and Development Division, Hokuriku Seiyaku Co., Ltd., Kanazawa, Katsuyama, Japan.© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKONTANI H and UEDA Y (2018) A METHOD FOR PRODUCING OVERACTIVE BLADDER IN THE RAT AND INVESTIGATION OF THE EFFECTS OF GABAergic RECEPTOR AGONISTS AND GLUTAMATERGIC RECEPTOR ANTAGONISTS ON THE CYSTOMETROGRAMJournal of Urology, VOL. 173, NO. 5, (1805-1811), Online publication date: 1-May-2005.YOTSUYANAGI S, YOKOYAMA O, KOMATSU K, KODAMA K, NAGASAKA Y and NAMIKI M (2018) ROLE OF CYCLOOXYGENASE-2 IN THE DEVELOPMENT OF BLADDER OVERACTIVITY AFTER CEREBRAL INFARCTION IN THE RATJournal of Urology, VOL. 174, NO. 1, (365-369), Online publication date: 1-Jul-2005.YOKOYAMA O, MIZUNO H, KOMATSU K, AKINO H, TANASE K and NAMIKI M (2018) ROLE OF GLUTAMATE RECEPTORS IN THE DEVELOPMENT AND MAINTENANCE OF BLADDER OVERACTIVITY AFTER CEREBRAL INFARCTION IN THE RATJournal of Urology, VOL. 171, NO. 4, (1709-1714), Online publication date: 1-Apr-2004.YOKOYAMA O, YOTSUYANAGI S, AKINO H, MORIYAMA N, MATSUTA Y and NAMIKI M (2018) RNA Synthesis in Pons Necessary for Maintenance of Bladder Overactivity After Cerebral Infarction in Rat.Journal of Urology, VOL. 169, NO. 5, (1878-1884), Online publication date: 1-May-2003.NAKAMURA Y, KONTANI H, TANAKA T, KOMATSU K, NAMIKI M and YOKOYAMA O (2018) Effects of Adenosine Triphosphate Dependent Potassium Channel Opener on Bladder Overactivity in Rats With Cerebral InfarctionJournal of Urology, VOL. 168, NO. 5, (2275-2279), Online publication date: 1-Nov-2002.Kaidoh K, Igawa Y, Takeda H, Yamazaki Y, Akahane S, Miyata H, Ajisawa Y, Nishizawa O and Andersson K (2018) Effects of Selective β2 and β3-Adrenoceptor Agonists on Detrusor Hyperreflexia in Conscious Cerebral Infarcted RatsJournal of Urology, VOL. 168, NO. 3, (1247-1252), Online publication date: 1-Sep-2002.KODAMA K, YOKOYAMA O, KOMATSU K, YOTSUYANAGI S, NIIKURA S and NAMIKI M (2018) CONTRIBUTION OF CEREBRAL NITRIC OXIDE TO BLADDER OVERACTIVITY AFTER CEREBRAL INFARCTION IN RATSJournal of Urology, VOL. 167, NO. 1, (391-396), Online publication date: 1-Jan-2002.YOTSUYANAGI S, YOKOYAMA O, KOMATSU K, KODAMA K, NIIKURA S and NAMIKI M (2018) EXPRESSION OF NEURAL PLASTICITY RELATED GENE IN THE PONTINE TEGMENTAL AREA OF RATS WITH OVERACTIVE BLADDER AFTER CEREBRAL INFARCTIONJournal of Urology, VOL. 166, NO. 3, (1148-1155), Online publication date: 1-Sep-2001.NAKAMURA Y, YOKOYAMA O, KOMATSU K, MITA E, NAMIKI M and KONTANI H (2018) EFFECTS OF NIFEDIPINE ON BLADDER OVERACTIVITY IN RATS WITH CEREBRAL INFARCTIONJournal of Urology, VOL. 162, NO. 4, (1502-1507), Online publication date: 1-Oct-1999. Volume 159Issue 2February 1998Page: 571-576 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information Osamu Yokoyama Requests for reprints: Department of Urology, School of Medicine, Kanazawa University, Takara-machi 13-1, Kanazawa 920, Japan. More articles by this author Yoshiyuki Ishiura More articles by this author Kazuto Komatsu More articles by this author Eiko Mita More articles by this author Yasuo Nakamura More articles by this author Kazuto Kunimi More articles by this author Kouji Morikawa More articles by this author Mikio Namiki More articles by this author Expand All Advertisement PDF downloadLoading ...