Produção Nacional
Vitamin D and diabetes mellitus: an update 2013
2014; Editora da Universidade de São Paulo; Volume: 58; Issue: 1 Linguagem: Inglês
10.1590/0004-2730000002535
ISSN1677-9487
AutoresLuiz Griz, Francisco Bandeira, Mônica Andrade Lima Gabbay, Sérgio Atala Dib, Eduardo Freese de Carvalho,
Tópico(s)Diet and metabolism studies
ResumoVitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH)2D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases.
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