Portal de Periódicos da CAPES

Synthesis of a chiral 1,7-dioxaspiro[5,5]undecene. A model for the spiroacetal subunit of avermectin B1a

1984; Elsevier BV; Volume: 130; Linguagem: Inglês

10.1016/0008-6215(84)85284-2

1873-426X

Stephen Hanessian, Antonio Ugolini,

Alkaloids: synthesis and pharmacology

Abstract The stereocontrolled synthesis of a chiral, polyhydroxy 1,7-dioxaspiro-[5,5]undecene from d -glucose is described. The bicyclic system with a different pattern of substitution can be found in a number of biologically important natural products such as the avermectins and the milbemycins.