Characterization of N ‐Demethyllincosamide Methyltransferases LmbJ and CcbJ
2013; Wiley; Volume: 14; Issue: 17 Linguagem: Inglês
10.1002/cbic.201300389
ISSN1439-7633
AutoresLucie Najmanová, Eva Kutějová, Jan Kadlec, Marek Poľan, Jana Olšovská, Oldřích Benada, Jitka Novotná, Zdeněk Kameník, Petr Halada, Jacob Bauer, Jiřı́ Janata,
Tópico(s)Chemical Synthesis and Analysis
ResumoChemBioChemVolume 14, Issue 17 p. 2259-2262 Communication Characterization of N-Demethyllincosamide Methyltransferases LmbJ and CcbJ Dr. Lucie Najmanová, Dr. Lucie Najmanová Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Eva Kutejová, Dr. Eva Kutejová Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Department of Biochemistry and Structural Biology, Institute of Molecular Biology SAS, Dúbravská cesta 21, 845 51 Bratislava (Slovakia)Search for more papers by this authorDr. Jan Kadlec, Dr. Jan Kadlec Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: European Molecular Biology Laboratory, Grenoble Outstation, 6 rue Jules Horowitz, B. P. 181, 38042 Grenoble Cedex 9 (France)Search for more papers by this authorMarek Polan, Marek Polan Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: The National Institute of Public Health, Centre for Epidemiology and Microbiology, National Reference Laboratory for Tuberculosis, Šrobárova 48, 100 42, Prague 10 (Czech Republic)Search for more papers by this authorDr. Jana Olšovská, Dr. Jana Olšovská Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: Research Institute of Brewing and Malting, PLC, Lípová 15, 120 44 Prague 2 (Czech Republic)Search for more papers by this authorDr. Oldřich Benada, Dr. Oldřich Benada Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Jitka Novotná, Dr. Jitka Novotná Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: Central European Institute of Technology, Masaryk University and National Centre for Biomolecular Research, Kamenice 735/5, 625 00 Brno (Czech Republic)Search for more papers by this authorDr. Zdeněk Kameník, Dr. Zdeněk Kameník Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Petr Halada, Dr. Petr Halada Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Jacob Bauer, Dr. Jacob Bauer Department of Biochemistry and Structural Biology, Institute of Molecular Biology SAS, Dúbravská cesta 21, 845 51 Bratislava (Slovakia)Search for more papers by this authorDr. Jiří Janata, Corresponding Author Dr. Jiří Janata [email protected] Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this author Dr. Lucie Najmanová, Dr. Lucie Najmanová Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Eva Kutejová, Dr. Eva Kutejová Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Department of Biochemistry and Structural Biology, Institute of Molecular Biology SAS, Dúbravská cesta 21, 845 51 Bratislava (Slovakia)Search for more papers by this authorDr. Jan Kadlec, Dr. Jan Kadlec Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: European Molecular Biology Laboratory, Grenoble Outstation, 6 rue Jules Horowitz, B. P. 181, 38042 Grenoble Cedex 9 (France)Search for more papers by this authorMarek Polan, Marek Polan Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: The National Institute of Public Health, Centre for Epidemiology and Microbiology, National Reference Laboratory for Tuberculosis, Šrobárova 48, 100 42, Prague 10 (Czech Republic)Search for more papers by this authorDr. Jana Olšovská, Dr. Jana Olšovská Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: Research Institute of Brewing and Malting, PLC, Lípová 15, 120 44 Prague 2 (Czech Republic)Search for more papers by this authorDr. Oldřich Benada, Dr. Oldřich Benada Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Jitka Novotná, Dr. Jitka Novotná Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic) Current address: Central European Institute of Technology, Masaryk University and National Centre for Biomolecular Research, Kamenice 735/5, 625 00 Brno (Czech Republic)Search for more papers by this authorDr. Zdeněk Kameník, Dr. Zdeněk Kameník Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Petr Halada, Dr. Petr Halada Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this authorDr. Jacob Bauer, Dr. Jacob Bauer Department of Biochemistry and Structural Biology, Institute of Molecular Biology SAS, Dúbravská cesta 21, 845 51 Bratislava (Slovakia)Search for more papers by this authorDr. Jiří Janata, Corresponding Author Dr. Jiří Janata [email protected] Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Institute of Microbiology AS CR, Vídeňská 1083, 142 20, Prague 4 (Czech Republic)Search for more papers by this author First published: 25 October 2013 https://doi.org/10.1002/cbic.201300389Citations: 21Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Chemical diversity: Two SAM-dependent N-methyltransferases—LmbJ from the biosynthesis of the antibiotic lincomycin and CcbJ from celesticetin biosynthesis—have been characterized and compared. Both tested enzymes form multimers and are able to utilize N-demethyllincomycin, the natural substrate of LmbJ, with comparable efficiency. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description cbic_201300389_sm_miscellaneous_information.pdf422.9 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume14, Issue17November 25, 2013Pages 2259-2262 RelatedInformation
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