Portal de Periódicos da CAPES

Carta Produção Nacional Revisado por pares

BIBTEX RIS

Polymorphism of the E‐cadherin gene CDH 1 is associated with susceptibility to vitiligo

2015; Wiley; Volume: 24; Issue: 4 Linguagem: Inglês

10.1111/exd.12641

1600-0625

Roberto Gomes Tarlé, Caio César Silva de Castro, Liliane Machado do Nascimento, Marcelo Távora Mira,

Mast cells and histamine

Vitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the DDR1 gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of DDR1 in vitiligo lesions. Here, we expand this investigation by testing for association between vitiligo and polymorphisms of CDH1, IL1B and NOV (formerly CCN3), genes belonging to the DDR1 adhesion pathway, in two population samples of distinct design. Our results reveal that alleles of marker rs10431924 of the CDH1 gene are associated with vitiligo, especially in the presence of autoimmune comorbidities.