Artigo Acesso aberto Produção Nacional Revisado por pares

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response

2014; Elsevier BV; Volume: 123; Issue: 26 Linguagem: Inglês

10.1182/blood-2013-12-545780

ISSN

1528-0020

Autores

Margareth C. Ozelo, B. Vidal, Christine Brown, Colleen Notley, Carol Hegadorn, Sandra Webster, Lori Harpell, James Ahlin, Andrew Winterborn, Janine Handforth, Valder R. Arruda, Christine Hough, David Lillicrap,

Tópico(s)

Chronic Myeloid Leukemia Treatments

Resumo

Key Points Implanting autologous FVIII-expressing BOECs results in sustained FVIII antigen in hemophilia dogs. Anti-FVIII immunoglobulin G2 antibodies develop.

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