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The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

2008; Elsevier BV; Volume: 29; Issue: 4 Linguagem: Inglês

10.1016/j.ccm.2008.06.010

1557-8216

Nick Ward, Brian Casserly, Alfred Ayala,

Inflammasome and immune disorders

Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.