Portal de Periódicos da CAPES

Genetics of Parkinson's disease: What do mutations in DJ‐1 tell us?

2003; Wiley; Volume: 54; Issue: 3 Linguagem: Inglês

10.1002/ana.10740

1531-8249

Darren J. Moore, Valina L. Dawson, Ted M. Dawson,

Autism Spectrum Disorder Research

Annals of NeurologyVolume 54, Issue 3 p. 281-282 Editorial Genetics of Parkinson's disease: What do mutations in DJ-1 tell us? Darren J. Moore PhD, Darren J. Moore PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this authorValina L. Dawson PhD, Valina L. Dawson PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD Neuroscience Johns Hopkins University School of Medicine, Baltimore, MD Physiology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this authorTed M. Dawson MD, PhD, Ted M. Dawson MD, PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD Neuroscience Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this author Darren J. Moore PhD, Darren J. Moore PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this authorValina L. Dawson PhD, Valina L. Dawson PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD Neuroscience Johns Hopkins University School of Medicine, Baltimore, MD Physiology, Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this authorTed M. Dawson MD, PhD, Ted M. Dawson MD, PhD Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD Departments of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD Neuroscience Johns Hopkins University School of Medicine, Baltimore, MDSearch for more papers by this author First published: 28 August 2003 https://doi.org/10.1002/ana.10740Citations: 8Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article. References 1 Giasson BI, Lee VM. Are ubiquitination pathways central to Parkinson's disease? Cell 2003; 114: 1– 8. 2 Dawson TM, Dawson VL. Rare genetic mutations shed light on the pathogenesis of Parkinson disease. J Clin Invest 2003; 111: 145– 151. 3 Lansbury PT, Jr., Brice A. Genetics of Parkinson's disease and biochemical studies of implicated gene products. Curr Opin Genet Dev 2002; 12: 299– 306. 4 Hardy J, Cookson MR, Singleton A. Genes and parkinsonism. Lancet Neurol 2003; 2: 221– 228. 5 Cookson MR. Pathways to Parkinsonism. Neuron 2003; 37: 7– 10. 6 Bonifati V, Rizzu P, Van Baren MJ, et al. Mutations in the DJ–1 Gene Associated with Autosomal Recessive Early–Onset Parkinsonism. Science 2002; 299: 256– 259. 7 Lucking CB, Durr A, Bonifati V et al. Association between early–onset Parkinson's disease and mutations in the parkin gene. French Parkinson's Disease Genetics Study Group. N Engl J Med 2000; 342: 1560– 1567. 8 Wilson MA, Collins JL, Hod Y, et al. The 1.1–A resolution crystal structure of DJ–1, the protein mutated in autosomal recessive early onset Parkinson's disease. Proc Natl Acad Sci USA 2003; in press. 9 Tao X, Tong L. Crystal structure of human DJ–1, a protein associated with early–onset Parkinson's diseasec. J Biol Chem 2003; in press. 10 Honbou K, Suzuki NN, Horiuchi M, et al. The crystal structure of DJ–1, a protein related to male fertility and Parkinson's disease. J Biol Chem 2003; in press. 11 Abou–Sleiman PM, Healy DG, Quinn N, et al. The role of pathogenic DJ–1 mutations in Parkinson's disease. Ann Neurol 2003; 54: 283– 286. 12 Hague S, Rogaeva E, Hernandez D, et al. Early–onset Parkinson's disease caused by a compound heterozygous DJ–1 mutation. Ann Neurol 2003; 54: 271– 274. Citing Literature Volume54, Issue3September 2003Pages 281-282 ReferencesRelatedInformation