Portal de Periódicos da CAPES

Comparison of the magnetic, radiolabeling, hyperthermic and biodistribution properties of hybrid nanoparticles bearing CoFe 2 O 4 and Fe 3 O 4 metal cores

2013; IOP Publishing; Volume: 25; Issue: 2 Linguagem: Inglês

10.1088/0957-4484/25/2/025101

1361-6528

Dimitrios Psimadas, Giovanni Baldi, Costanza Ravagli, Mauro Comes Franchini, Erica Locatelli, Claudia Innocenti, Claudio Sangregorio, George Loudos,

Magnetic Properties and Synthesis of Ferrites

Metal oxide nanoparticles, hybridized with various polymeric chemicals, represent a novel and breakthrough application in drug delivery, hyperthermia treatment and imaging techniques. Radiolabeling of these nanoformulations can result in new and attractive dual-imaging agents as well as provide accurate in vivo information on their biodistribution profile. In this paper a comparison study has been made between two of the most promising hybrid core–shell nanosystems, bearing either magnetite (Fe3O4) or cobalt ferrite (CoFe2O4) cores, regarding their magnetic, radiolabeling, hyperthermic and biodistribution properties. While hyperthermic properties were found to be affected by the metal-core type, the radiolabeling ability and the in vivo fate of the nanoformulations seem to depend critically on the size and the shell composition.