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In Vitro Anti‐ Mycobacterium avium Activity of N ‐(2‐Hydroxyethyl)‐1,2‐benzisothiazol‐3(2 H )‐one and ‐thione Carbamic Esters

1996; Wiley; Volume: 329; Issue: 8-9 Linguagem: Inglês

10.1002/ardp.19963290810

1521-4184

Giuseppe Pagani, P Borgna, Claudio Piersimoni, Domenico Nista, Marco Terreni, Massimo Pregnolato,

Infectious Diseases and Mycology

Abstract A series of N ‐(2‐hydroxyethyl)‐1,2‐benzisothiazol‐3(2 H )‐one and ‐thione carbamic esters have been synthesised and tested against Mycobacterium avium strains. The MIC values determined by the radiometric broth dilution method were between 2 and 8 μg/mL for the benzisothiazolthione derivatives and between 16 and 32 μg/mL or higher for the corresponding benzisothiazolone derivatives.