MK-801, a non-competitive NMDA receptor antagonist, produces facilitation of the micturition reflex in awake, freely-moving rats
1991; Elsevier BV; Volume: 134; Issue: 1 Linguagem: Inglês
10.1016/0304-3940(91)90525-x
ISSN1872-7972
AutoresPedro L. Vera, Irving Nadelhaft,
Tópico(s)Ion channel regulation and function
ResumoMK-801 (dizocilpine), a non-competitive N-methyl-d-aspartate (NMDA) receptor blocker, produced a dose-dependent (30–120 μg/kg, i.v.) increase in the frequency of micturition (as well as the already described behavioral effects) in awake, freely-moving rats. The contraction amplitude was also slightly increased. In contrast, MK-801 administered to urethane-anesthetized rats resulted in complete inhibition of bladder contractions. The effect of MK-801 on the frequency of bladder contractions, therefore, is anesthetic dependent. Excitatory amino acids acting at NMDA receptors may play a role in the control of micturition.
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