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Pioneer Axon Guidance by UNC-129, a C. elegans TGF-β

1998; American Association for the Advancement of Science; Volume: 281; Issue: 5377 Linguagem: Inglês

10.1126/science.281.5377.706

1095-9203

A. Colavita, Srikant Krishna, Hong Zheng, Richard W. Padgett, Joseph G. Culotti,

Apelin-related biomedical research

The unc-129 gene, like the unc-6 netrin gene, is required to guide pioneer motoraxons along the dorsoventral axis of Caenorhabditis elegans . unc-129 encodes a member of the transforming growth factor–β (TGF-β) superfamily of secreted signaling molecules and is expressed in dorsal, but not ventral, rows of body wall muscles. Ectopic expression of UNC-129 from ventral body wall muscle disrupts growth cone and cell migrations that normally occur along the dorsoventral axis. Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans .