Total Synthesis of Salinosporamide A
2008; American Chemical Society; Volume: 10; Issue: 19 Linguagem: Inglês
10.1021/ol8016066
ISSN1523-7060
AutoresTakeo Fukuda, Kouhei Sugiyama, Shiho Arima, Yoshihiro Harigaya, Tohru Nagamitsu, Satoshi Ōmura,
Tópico(s)Marine Sponges and Natural Products
ResumoThe total synthesis of salinosporamide A has been achieved through enzymatic desymmetrization, diastereoselective aldol reaction, intramolecular aldol reaction, and intermolecular Reformatsky-type reaction followed by 1,4-reduction as key reactions.
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