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AGE AT UNILATERAL ORCHIOPEXY: EFFECT ON HORMONE LEVELS AND SPERM COUNT IN ADULTHOOD

1999; Lippincott Williams & Wilkins; Volume: 162; Issue: 3 Part 2 Linguagem: Inglês

10.1016/s0022-5347(01)68040-6

1527-3792

Michael T. Coughlin, Mark F. Bellinger, Peter A. Lee,

Sexual Differentiation and Disorders

No AccessJournal of UrologyPapers Presented at Annual Meeting of the Section on Urology, American Academy of Pediatrics; San Francisco, California; October 17-19, 1998: Testes1 Sep 1999AGE AT UNILATERAL ORCHIOPEXY: EFFECT ON HORMONE LEVELS AND SPERM COUNT IN ADULTHOOD MICHAEL T. COUGHLIN, MARK F. BELLINGER, and PETER A. LEE MICHAEL T. COUGHLINMICHAEL T. COUGHLIN , MARK F. BELLINGERMARK F. BELLINGER , and PETER A. LEEPETER A. LEE View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68040-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether there are differences in hormone levels, such as inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone and testosterone, and sperm density in men with a history of unilateral cryptorchidism as stratified by age at orchiopexy. Materials and Methods: A total of 84 men with a history of unilateral cryptorchidism presented to our institution for serum hormone measurement and semen analysis. These parameters were compared using Pearson's correlations and analysis of variance among 4 groups stratified according to age at orchiopexy (range 1 month to 11 years). Results: Comparison by Pearson's correlation analysis showed that age at orchiopexy significantly correlated inversely with inhibin B (r = -0.274, p = 0.012) and positively correlated with FSH (r = 0.229, p = 0.036). Comparison of mean hormone levels and sperm density by analysis of variance for linear trend revealed a significant relationship between age at surgery with inhibin B (p = 0.032) and testosterone (p = 0.029), while sperm density, FSH and luteinizing hormone were not significantly related. Post hoc comparison of individual means at surgery and at the time of this study demonstrated a significantly higher inhibin B level in the youngest age group than in 2 of the 3 older groups. Conclusions: Men who previously had unilateral cryptorchidism and who underwent orchiopexy by age 2 years have higher inhibin B and lower FSH profiles than those who underwent surgery later in life. This finding suggests an overall beneficial effect of early orchiopexy in boys born with unilateral cryptorchidism. References 1 : Cryptorchidism, orchiopexy, and infertility: a critical long-term retrospective analysis. J. Urol.1989; 142: 559. Link, Google Scholar 2 : Cryptorchidism. In: . Chicago: Year Book Medical Pub.1987: 1974. chapt. 59C. Google Scholar 3 : Cryptorchidism: histologic study of 220 biopsies with clinico-anatomical correlations. In: . Basel: S. Karger1979: 14. Google Scholar 4 : Postnatal testicular maldevelopment in unilateral cryptorchidism. J. Urol.1989; 142: 546. 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