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Role of estrogen receptor α in membrane-initiated signaling in neural cells: Interaction with IGF-1 receptor

2009; Elsevier BV; Volume: 114; Issue: 1-2 Linguagem: Inglês

10.1016/j.jsbmb.2008.12.014

1879-1220

Raquel Marín, Mario Dı́az, Rafael Alonso, Amaya Sanz, María‐Ángeles Arévalo, Luis Miguel García‐Segura,

Estrogen and related hormone effects

The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERα interacts with the signaling of IGF-1 receptor in neural cells: ERα transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERα and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERα and IGF-I receptor.