Produção Nacional
Revisado por pares
Reactive oxygen and nitrogen species balance in the determination of thyroid hormones-induced cardiac hypertrophy mediated by renin–angiotensin system
2010; Elsevier BV; Volume: 333; Issue: 1 Linguagem: Inglês
10.1016/j.mce.2010.12.018
ISSN1872-8057
AutoresAlex Sander da Rosa Araújo, Gabriela Placoná Diniz, Fernanda Eugênia Rodrigues Seibel, Gisele Branchini, Maria Flávia Marques Ribeiro, Ilma Simoni Brum, Neelam Khaper, Maria Luiza Morais Barreto‐Chaves, A. Belló-Klein,
Tópico(s)Nitric Oxide and Endothelin Effects
ResumoRole of reactive oxygen species (ROS)/nitric oxide (NO) balance and renin–angiotensin system in mediating cardiac hypertrophy in hyperthyroidism was evaluated in an in vivo and in vitro experimental model. Male Wistar rats were divided into four groups: control, thyroid hormone, vitamin E (or Trolox, its hydrosoluble analogue), thyroid hormone + vitamin E. Angiotensin II receptor (AT1/AT2) gene expression, immunocontent of AT1/AT2 receptors, angiotensinogen, NADPH oxidase (Nox2), and nitric oxide synthase isoforms, as well as ROS concentration (hydrogen peroxide and superoxide anion) were quantified in myocardium. Thyroid hormone increased ROS and NO metabolites, iNOS, nNOS and eNOS isoforms and it was accompanied by cardiac hypertrophy. AT1/AT2 expression and the immunocontent of angiotensinogen and Nox2 were enhanced by thyroid hormone. Antioxidants reduced ROS levels, Nox2, AT1/AT2, NOS isoforms and cardiac hypertrophy. In conclusion, ROS/NO balance may play a role in the control of thyroid hormone-induced cardiac hypertrophy mediated by renin–angiotensin system.
Referência(s)