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Left ventricular infarct size, peri‐infarct zone, and papillary scar measurements: A comparison of high‐resolution 3D and conventional 2D late gadolinium enhancement cardiac MR

2009; Wiley; Volume: 30; Issue: 4 Linguagem: Inglês

10.1002/jmri.21897

1522-2586

Dana C. Peters, Evan Appelbaum, Reza Nezafat, Basem Dokhan, Yuchi Han, Kraig V. Kissinger, Beth Goddu, Warren J. Manning,

Cardiovascular Function and Risk Factors

Abstract Purpose To compare higher spatial resolution 3D late gadolinium enhancement (LGE) cardiovascular magnetic resonance (Cardiac MR) with 2D LGE in patients with prior myocardial infarction. Materials and Methods Fourteen patients were studied using high spatial resolution 3D LGE (1.3 × 1.3 × 5.0 mm 3 ) and conventional 2D LGE (2 × 2 × 8 mm 3 ) scans. The signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) were measured. Total infarct volume, peri‐infarct volume measured in a limited slab, and papillary muscle scar volume were compared using Bland–Altman analysis. Image quality was graded. Results 3D LGE had higher scar SNR ( P < 0.001), higher myocardial SNR ( P = 0.001), higher papillary scar‐blood CNR ( P = 0.01), and greater sharpness ( P = 0.01). The scar volumes agreed (14.5 ± 8.2 for 2D, vs. 13.2 ± 8.8 for 3D), with bias ± 2 standard deviations (SDs) of 0.5 ± 6.8 mL, P = 0.59 R = 0.91. The peri‐infarct volumes correlated but less strongly than scar ( P = 0.40, R = 0.77). For patients with more heterogeneous scar, larger peri‐infarct volumes were measured by 3D (1.9 ± 1.1 mL for 2D vs. 2.4 ± 1.6 mL for 3D, P = 0.15, in the matched region). Papillary scar, present in 6/14 (42%) patients, was more confidently identified on 3D LGE. Conclusion Higher spatial resolution 3D LGE provides sharper images and higher SNR, but less myocardial nulling. Scar volumes agree well, with peri‐infarct volumes correlating less well. 3D LGE may be superior in visualization of papillary muscle scar. J. Magn. Reson. Imaging 2009;30:794–800. © 2009 Wiley‐Liss, Inc.