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A New Anti-HIV Alkaloid, Drymaritin, and a New C-Glycoside Flavonoid, Diandraflavone, from Drymaria d iandra

2004; American Chemical Society; Volume: 67; Issue: 7 Linguagem: Inglês

10.1021/np0400196

1520-6025

Pei‐Wen Hsieh, Fang‐Rong Chang, Kuo‐Hsiung Lee, Tsong‐Long Hwang, Sue-Ming Chang, Yang‐Chang Wu,

Bioactive Compounds and Antitumor Agents

A novel anti-HIV alkaloid, drymaritin (1), and a new C-glycoside flavonoid, diandraflavone (2), along with eight known compounds, torosaflavone A, isovitexin, spinasterol β-d-glycoside, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, cis-p-coumarate, methyl 5-hydroxy-4-oxopentanoate, and glycerol-α-lignocerate, were isolated from Drymaria diandra. Drymaritin (1) exhibited anti-HIV effects in H9 lymphocytes with an EC50 value of 0.699 μg/mL and a TI of 20.6. Compound 2 showed significantly selective inhibition on superoxide anion generation from human neutrophils stimulated by fMLP/CB with an IC50 value of 10.0 μg/mL.