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The Formylation of Amino Acids with Acetic Formic Anhydride

1965; Oxford University Press; Volume: 38; Issue: 2 Linguagem: Inglês

10.1246/bcsj.38.244

1348-0634

Ichiro Muramatsu, Masahiro Murakami, Takahiro Yoneda, Akira Hagitani,

Synthesis and Biological Activity

Abstract The formylation of amino acids with acetic formic anhydride has been studied. This anhydride is prepared by the reaction of acetyl chloride with sodium formate or, preferably, from ketene and formic acid. When various monoamino monocarboxylic acids are treated with acetic formic anhydride by a simple procedure and under mild conditions, N-formylamino acids were obtained in satisfactory yields.