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The genetics of anorexia nervosa collaborative study: Methods and sample description

2008; Wiley; Volume: 41; Issue: 4 Linguagem: Inglês

10.1002/eat.20509

1098-108X

Walter H. Kaye, Cynthia M. Bulik, Katherine Plotnicov, Laura M. Thornton, Bernie Devlin, Manfred M. Fichter, Janet Treasure, Allan S. Kaplan, D. Blake Woodside, Craig L. Johnson, Katherine A. Halmi, Harry Brandt, Steve Crawford, James E. Mitchell, Michael Strober, Wade H. Berrettini, Ian Jones,

Impact of Technology on Adolescents

Supported by National Institute of Mental Health (NIMH), this 12-site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN).Four hundred families will be ascertained with two or more individuals affected with AN. The assessment battery produces a rich set of phenotypes comprising eating disorder diagnoses and psychological and personality features known to be associated with vulnerability to eating disorders.We report attributes of the first 200 families, comprising 200 probands and 232 affected relatives.These results provide context for the genotyping of the first 200 families by the Center for Inherited Disease Research. We will analyze our first 200 families for linkage, complete recruitment of roughly 400 families, and then perform final linkage analyses on the complete cohort. DNA, genotypes, and phenotypes will form a national eating disorder repository maintained by NIMH and available to qualified investigators.