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Urinary Biomarkers as Indicators of Renal Disease

1999; Taylor & Francis; Volume: 21; Issue: 3-4 Linguagem: Inglês

10.3109/08860229909085086

1525-6049

Richard P. Wedeen, Iris Udasin, Nancy Fiedler, Patrick C. D’Haese, Marc De Broe, Emilio Gelpı́, Keith Jones, Michael Gochfeld,

Chronic Kidney Disease and Diabetes

Using modern technology, minute quantities of LMWP, prostanoids, growth factors, intra-renal and extra-renal enzymes can be measured in urine. Excretory patterns that are characteristic for site and mechanism of renal injury often can be found. It is possible to recognise urinary biomarker patterns that suggest the putative environmental nephrotoxin. Our own studies performed in subjects with low level occupational and environmental exposures in New Jersey confirm the pattern specificity and threshold effects for Cr, Hg and Pb. In addition, we have been able to show that increased NAG and LAP excretion following Pb exposure correlates with current (blood Pb) but not with the cumulative Pb burden (bone Pb). The relatively specific characteristic patterns of biomarker excretion are lost as renal failure progresses. Moreover, renal injury that results in tubular proteinuria may not progress to renal failure. Nevertheless, urine biomarkers can help to establish acceptable levels and identify the need for long term surveillance to ascertain when clinical renal disease may result.