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BIBTEX RIS

The effects of essential oil ofMentha x villosa on skeletal muscle of the toad

1997; Wiley; Volume: 11; Issue: 8 Linguagem: Inglês

10.1002/(sici)1099-1573(199712)11

1099-1573

R. T. H. Fogaça, A. D. A. Cavalcante, A. K. L. Serpa, Pergentino José C. Sousa, Andrelina Noronha Coelho‐de‐Souza, José Henrique Leal‐Cardoso,

Muscle activation and electromyography studies

The effects of the essential oil of Mentha x villosa (EOMV) was investigated in saponin-permeabilized fibres and in intact sartorius muscle of the toad. In intact muscle EOMV at concentrations from 1 to 100 μg/mL blocked the contraction induced by high (80 mM) potassium and induced potentiation of caffeine-induced muscle contraction. From 1 to 6 mg/mL EOMV elicited contraction in both depolarized (by 110 mM K+) and non-depolarized (4 mM K+) muscle fibres. This contraction was blocked by procaine. At 3 mg/mL EOMV depolarized the normal resting potential from −80.77 to −71.21 mV, but did not alter the transmembrane potential in the presence of 60 mM K+. EOMV (1 mg/mL) induced contraction of saponin-permeabilized muscle fibres with an intact sarcoplasmic reticulum (SR). These data suggest that EOMV: (i) induces muscle contraction by releasing Ca2+ from SR; (ii) impairs the excitation–contraction coupling at a step before Ca2+ release from the SR. © 1997 John Wiley & Sons, Ltd.