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Subcutaneous and Perineural Botulinum Toxin Type A For Neuropathic Pain

2013; Lippincott Williams & Wilkins; Volume: 29; Issue: 11 Linguagem: Inglês

10.1097/ajp.0b013e31827eafff

1536-5409

Gustavo Fabregat‐Cid, Jose De Andrés, Vicente Luis Villanueva Pérez, Juan Marcos Asensio‐Samper,

Pain Management and Treatment

Botulinum toxin is a neurotoxin that has been widely used in chronic pain for the treatment of multiple conditions with a component of localized muscle spasm. Recent studies suggest that botulinum toxin is effective in the treatment of neuropathic pain syndromes such as postherpetic neuralgia or painful scars.We searched the PubMed and OvidSP databases. We also included cross-referencing bibliographies from primary and review articles.In this descriptive review, we evaluate the usefulness, safety, and potential pathophysiological mechanism of botulinum toxin type A for treatment of painful disorders with neuropathic component such as postherpetic neuralgia, diabetic neuropathy, or trigeminal neuralgia.On the basis of the analysis of the reports published in the literature, it would seem that fractioned peripheral subcutaneous and perineural injections of botulinum toxin type A may be useful for the treatment of various chronic pain conditions with neuropathic component.