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Crystal Structure of a Naturally Occurring Dinucleoside Monophosphate: Uridylyl (3′,5′) Adenosine Hemihydrate

1971; American Association for the Advancement of Science; Volume: 174; Issue: 4013 Linguagem: Inglês

10.1126/science.174.4013.1020

1095-9203

John R. Rubin, Tim Brennan, M. Sundaralingam,

RNA modifications and cancer

The crystal structure of uridylyl (3',5') adenosine hemihydrate has been analyzed by x-ray diffraction. The two independent molecules found in the asymmetric unit exhibit conformations that differ significantly from those found in double-helical RNA. The conformational information obtained from this analysis provides considerable insight into the possible conformations of nonhelical "loop" regions of transfer RNA, as well as single-stranded regions of nucleic acids in general.