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Human cytotoxic T-lymphocytes specific for autologous follicular lymphoma recognize immunoglobulin in a major histocompatibility complex restricted fashion

1992; Wiley; Volume: 70; Issue: 8 Linguagem: Inglês

10.1002/1097-0142(19921015)70

1097-0142

Sandra Luna-Finerman, Jeffrey E. Lee, Pamela K. Wesley, Carol Clayberger, Alan M. Krensky,

T-cell and B-cell Immunology

Background. Previously, autologous Burkitt lymphoma-specific cytotoxic T-lymphocytes (CTL) were found to express the gamma and delta T-cell receptor and recognize tumor idiotype in a major histocompatibility complex (MHC) unrestricted fashion. Methods. In this study, the authors established autologous CTL lines and clones specific for a B-cell follicular lymphoma. Results. These CTL are tumor specific and inhibited by antiimmunoglobulin monoclonal antibodies, but unlike the Burkitt lymphoma-specific CTL, they are MHC restricted and express the alpha and beta T-cell receptor. Conclusions. These studies suggest that different B-cell lymphomas can induce CTL of different phenotypes and MHC restriction.