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Fish are like flies are like frogs: Conservation of dorsal‐ventral patterning mechanisms

1997; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês

10.1002/bies.950190404

1521-1878

Scott A. Holley, Edwin L. Ferguson,

Axon Guidance and Neuronal Signaling

Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor-beta family member dpp patterns the embryonic dorsal-ventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal-ventral patterning in the zebrafish Danio rerio. Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate.