Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
1990; American Association for the Advancement of Science; Volume: 248; Issue: 4959 Linguagem: Inglês
10.1126/science.2111583
ISSN1095-9203
AutoresFred Esch, Pamela S. Keim, Eric C. Beattie, Russell Blacher, Alan R. Culwell, Tilman Oltersdorf, Donald McClure, Pamela J. Ward,
Tópico(s)Protein Structure and Dynamics
ResumoThe amyloid β peptide (AβP) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant AβP deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the AβP, thus preventing AβP deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.
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