Complementary addressed modification of nucleic acids with the alkylating derivatives of oligothymidylate ethyl phosphotriesters Effect of the phosphotriester fragments' configuration
1988; Wiley; Volume: 236; Issue: 1 Linguagem: Inglês
10.1016/0014-5793(88)80323-5
ISSN1873-3468
AutoresTatyana V. Abramova, Valentin V. Vlassov, Alexandre Lebedev, A. S. Ryte,
Tópico(s)RNA and protein synthesis mechanisms
ResumoThe alkylating derivatives of four individual diastereomers of the oligonucleotide [dTp(Et)]3dTpU and two individual diastereomers of oligonucleotide [dTp(Et)dTp]4 have been synthesized. The reagents with the phosphorus atoms in the enantiomeric p" configuration are shown to be more efficient in reacting with poly(dA) and with nucleic acids in Krebs-2 ascites carcinoma cells compared to those with the phosphorus atoms in the p' configuration.
Referência(s)