Capecitabine and Celecoxib as Second-Line Treatment of Advanced Pancreatic and Biliary Tract Cancers
2009; Karger Publishers; Volume: 76; Issue: 4 Linguagem: Inglês
10.1159/000205388
ISSN1423-0232
AutoresMaria Simona Pino, Michèle Milella, Alain Gelibter, Isabella Sperduti, Salvatore De Marco, Carmen Nuzzo, Emilio Bria, L Carpanese, Enzo Maria Ruggeri, Paolo Carlini, Francesco Cognetti,
Tópico(s)Drug Transport and Resistance Mechanisms
Resumo<i>Objective:</i> An increasing number of patients with advanced pancreatic or biliary tract cancer who progress after a gemcitabine-containing regimen are candidates for further chemotherapy. We therefore evaluated a fully oral regimen of capecitabine and celecoxib (CapCel) as second-line treatment in these patients. <i>Methods:</i> Thirty-five patients with documented progressive disease after first-line treatment were enrolled. Capecitabine was administered at a dose of 1,000 mg/m<sup>2</sup> b.i.d. for 2 consecutive weeks followed by 1 week of rest; celecoxib was given continuously at 200 mg b.i.d. Progression-free survival at 3 months was the primary study endpoint. <i>Results:</i> The CapCel combination was associated with an overall response rate of 9% and median survival duration of 19 weeks. Sixty percent of patients were free from progression 3 months after the start of treatment. Multivariate analysis identified a positive clinical benefit response and a decline in CA 19.9 serum levels >25% compared with baseline levels as independent predictors of prolonged survival. The treatment protocol was well tolerated with negligible hematological toxicity. The most common grade 3 non-hematological toxicities were hypertransaminasemia, diarrhea and asthenia. <i>Conclusions:</i> The CapCel combination is a safe treatment option with moderate activity in patients with pancreatic/biliary tract cancer after failure of a previous gemcitabine-containing regimen.
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