Portal de Periódicos da CAPES

Towards the design of combination therapy for the treatment of enterovirus infections

2011; Elsevier BV; Volume: 90; Issue: 3 Linguagem: Inglês

10.1016/j.antiviral.2011.03.187

1872-9096

Hendrik Jan Thibaut, Pieter Leyssen, Gerhard Puerstinger, Alexandra Muigg, Johan Neyts, Armando M. De Palma,

Immunodeficiency and Autoimmune Disorders

We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the selected molecules (Pleconaril, BTA-798 and V-073) are in clinical development. The in vitro antiviral activity of pairwise combinations of inhibitors indicated that most combinations resulted in an additive to slightly synergistic antiviral activity. However, the combination of ribavirin with a nucleoside polymerase inhibitor resulted in a pronounced antagonistic effect.