Prevention of severe phantom limb pain by perioperative administration of ketamine—an observational study
2002; Elsevier BV; Volume: 4; Issue: 1 Linguagem: Inglês
10.1016/s1366-0071(02)00004-9
ISSN1873-6319
AutoresRoman Dertwinkel, Claudia Heinrichs, Isabel Senne, Martin Tegenthoff, Thomas Weiß, J.-P. Malin, M. Zenz, Christoph Maier,
Tópico(s)Cardiac, Anesthesia and Surgical Outcomes
ResumoIn a prospective, observational study (n=14) with historical controls (n=14) the administration of the N-methyl-d-aspartate (NMDA)-antagonist ketamine intra- and 72 h postoperatively led to significant reduction of severe phantom limb pain, exceeding the intensity of three on the numeric rating scale (NRS). However, the incidence of all phantom limb pain remained high at 72%. On follow-up (median: 557 days), only one patient (9%) after ketamine, whereas 10 patients (71%) in the control group complained of severe phantom limb pain. These results have to be confirmed by a randomised placebo-controlled trial, regarding severity and daily relevance of painful sensations.
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