Hypoglycaemic Effect of Lycopene in Streptozotocin-Induced Diabetic Wistar Rats
2015; Sciencedomain International; Volume: 7; Issue: 9 Linguagem: Inglês
10.9734/bjmmr/2015/15908
ISSN2231-0614
AutoresEjike Daniel Eze, Aliyu Mohammed, Y Tanko, Abubakar Ahmed, Karimah Mohammed Rabiu,
Tópico(s)Diet, Metabolism, and Disease
ResumoAim:The study was designed to investigate the hypoglycaemic potential of lycopene in streptozotocin (STZ)-induced diabetic Wistar rats.Methodology: To achieve this, a total of thirty (30) adult Wistar rats of both sexes were used.The animals were made diabetic by single intraperitoneal injection of freshly prepared (60 mg/kg body weight) of STZ.Diabetes was confirmed by the presence of high blood glucose ≥ 200 after 72 hr.Diabetic animals were divided into six ( 6) groups (1, 2, 3, 4, 5 and 6) comprising five animals each.Animals in Group 1 (Diabetic control) and Group 2 (Normal control) received 0.5 ml of olive oil, while those in groups 2, 3, 4, 5 and 6 were administered 10, 20, 40 and 2 mg/kg b w of lycopene Original Research Article
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