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Fast optical monitoring of microscopic excitation patterns in cardiac muscle

1989; Elsevier BV; Volume: 56; Issue: 3 Linguagem: Inglês

10.1016/s0006-3495(89)82709-2

1542-0086

Wolfram Müller, H. Windisch, H. A. Tritthart,

Neural dynamics and brain function

Many vital processes de- Here, an exceptionally fast array rat cardiac muscle in vitro.Results pend on the generation, changes, and system (16 x 16 photodiodes, up to emphasize a recent hypothesis for car- conduction of cellular transmembrane 4,000,000 samples per second, 12-bit diac impulse conduction, based on car- potentials.Optical monitoring systems resolution) for imaging voltage-sensi-diac structural complexities, that is are well suited to detect such cellular tive dye fluorescence, permitted real contradictory to all continuous cable electrical activities in networks of excittime measurements of excitation pat-theory models.able cells and also tissues simultaterns at a microscopic size scale (256 neously at multiple sites.pixels within an area of 1.8-8 mm2), in . . . . . . .