Construction of a Spirooxindole Amide Library through Nitrile Hydrozirconation-Acylation-Cyclization Cascade
2013; American Chemical Society; Volume: 15; Issue: 7 Linguagem: Inglês
10.1021/co4000387
ISSN2156-8952
AutoresMatthew G. LaPorte, Sammi Tsegay, Ki Bum Hong, Chunliang Lu, Cheng Fang, Lirong Wang, Xiang‐Qun Xie, Paul E. Floreancig,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoA library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.
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