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Werner's Syndrome

1965; American College of Physicians; Volume: 63; Issue: 2 Linguagem: Inglês

10.7326/0003-4819-63-2-285

1539-3704

Thomas Riley,

melanin and skin pigmentation

Case Studies1 August 1965Werner's SyndromeTHOMAS R. RILEY, M.D., RALPH G. WIELAND, M.D., JOHN MARKIS, B.A., GEORGE J. HAMWI, M.D., F.A.C.P.THOMAS R. RILEY, M.D.Search for more papers by this author, RALPH G. WIELAND, M.D.Search for more papers by this author, JOHN MARKIS, B.A.Search for more papers by this author, GEORGE J. HAMWI, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-285 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOtto Werner (1), as a medical student at the Ophthalmology Clinic in Kiel, studied four siblings with cataracts and scleroderma whom he described in 1904 in his doctoral dissertation. In 1868, Rothmund (2) had reported three families whose members were afflicted with cataracts and a peculiar telangiectatic dermatological condition. The similarity between these syndromes resulted in considerable confusion, and for years investigators did not distinguish one from the other. In 1934, Oppenheimer and Kugel (3) described for the first time in the American literature two patients similar to those of Werner. They emphasized the difference between these patients and those...References1. WERNER CW: Über Katarakt in Ver. bindung mit Sclerodermie, in Inaug. Dissert. Kiel, 1904. Google Scholar2. ROTHMUND A: Über Katarakt in Verbindung mit einer eigentumlichen Hautdegeneration. Arch. Opthal. (Chicago) 14: 159, 1868. Google Scholar3. OPPENHEIMERKUGEL BSVH: Werner's syndrome—a heredofamilial disorder with scleroderma, bilateral juvenile cataract, precocious graying of the hair and endocrine stigmatization. Trans. Ass. Amer. Physicians 49: 358, 1934. Google Scholar4. THANNHAUSER SJ: Werner's syndrome (progeria of the adult) and Rothmund's syndrome: two types of closely related heredofamilial atrophic dermatoses with juvenile cataracts and endocrine features; a critical study with five new cases. Ann. Intern. Med. 23: 559, 1945. LinkGoogle Scholar5. MAEDER G: Le syndrome de Rothmund et le syndrome de Werner. Ann. Oculist (Paris) 182: 809, 1949. MedlineGoogle Scholar6. IRWINWARD GWPB: Werner's syndrome with a report of two cases. Amer. J. Med. 15: 266, 1953. CrossrefMedlineGoogle Scholar7. PETROHELOS MA: Werner's syndrome: a survey of three cases, with a review of the literature. Amer. J. Ophthal. Series 3 56: 941, 1963. CrossrefMedlineGoogle Scholar8. KALLOSRUPPE AJP: Werner's syndrome. New York J. Med. 54: 2180, 1954. MedlineGoogle Scholar9. GRANT AP: Werner's syndrome (progeria in the adult). Ulster Med. J. 26: 65, 1957. MedlineGoogle Scholar10. OPPENHEIMERKUGEL BSVH: Werner's syndrome: report of the first necropsy and of findings in a new case. Amer. J. Med. Sci. 202: 629, 1941. CrossrefGoogle Scholar11. SMITHWINERMARTEL RCLHS: Werner's syndrome, report of two cases. Arch. Derm. (Chicago) 71: 197, 1955. CrossrefGoogle Scholar12. TALBOTBUTLERPRATTMACLACHENTHANNHEIMER NBAMELEAJ: Progeria, clinical metabolic and pathologic studies. Amer. J. Dis. Child. 69: 267, 1945. CrossrefGoogle Scholar13. MULLERANDERSON LB: Werner's syndrome, a survey based on two cases. Acta Med. Scand., Supplementum 283 146: 1, 1953. Google Scholar14. BAUERCONN JMJW: Werner's syndrome: a study of adrenocortical and hepatic steroidal metabolism. Texas J. Med. 49: 882, 1953. MedlineGoogle Scholar15. REEDSEVILLETATTERSAL RRHRN: Werner's syndrome. Brit. J. Derm. 65: 165, 1953. CrossrefMedlineGoogle Scholar16. CHALMERSPAWANKERWICK TMGLA: Fat mobilizing activity of human urine extract. Amer. J. Clin. Nutr. 8: 728, 1960. CrossrefGoogle Scholar17. SPACKMANSTEINMOORE DHWHS: Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30: 1190, 1958. CrossrefGoogle Scholar18. SCHOTTDANN JS: Werner's syndrome: a report of two cases. New Eng. J. Med. 240: 641, 1949. CrossrefMedlineGoogle Scholar19. SHEETS RF: Werner's syndrome (progeria of the adult). Amer. Pract. 1: 390, 1950. Google Scholar20. DEUCHAR DC: Werner's syndrome. Proc. Royal Soc. Med. 49: 316, 1956. MedlineGoogle Scholar21. WILBER I: Werner's syndrome. J. Amer. Med. Wom. Ass. 15: 584, 1960. MedlineGoogle Scholar22. SULZBERGER MB: Dyshormonal dermatosis (Werner's syndrome). Arch. Derm. Syph. (Berl.) 36: 1256, 1937. Google Scholar23. BRODEYRUPPE AJ: Werner's syndrome. Arch. Derm. Syph. (Berl.) 69: 243, 1954. MedlineGoogle Scholar24. WILLIAMS DI: Werner's syndrome. Proc. Roy. Soc. Med. 42: 572, 1949. CrossrefMedlineGoogle Scholar25. MCKUSICK VA: Medical genetics—1962. J. Chronic Dis. 16: 457, 1963. CrossrefMedlineGoogle Scholar26. MOTULSKYSCHULTZPRIEST AGAJ: Werner's syndrome: chromosomes, genes, and the aging process. Lancet 1: 160, 1962. CrossrefGoogle Scholar27. FRACCAROBOTTCALVERT MMGHT: Chromosomes in Werner's syndrome. Ibid., p. 536. Google Scholar28. LEARNERDAYWEISSGEORGE NHJLAD: Chromosomes in Werner's syndrome. Ibid. Google Scholar29. COHENSHELLY MW: Ankle ulcer sign of Werner's syndrome. Arch. Derm. (Chicago) 87: 86, 1963. CrossrefMedlineGoogle Scholar30. EARL CJ (presented by Blau, J. N.): A case of Werner's syndrome. Proc. Roy. Soc. Med. 55: 328, 1962. CrossrefMedlineGoogle Scholar31. TUCHWEBERGRABBIANISELYE BGH: Effect of vitamin E and methyltestosterone upon the progeria-like syndrome produced by dihydrotachysterol. Amer. J. Clin. Nutr. 13: 238, 1963. CrossrefMedlineGoogle Scholar32. SELYESTREBELMIKULAZ HRL: A progeria-like syndrome produced by dihydrotachysterol and its prevention by methyltestosterone and ferric dextran. J. Amer. Geriat. Soc. 11: 1, 1963. CrossrefMedlineGoogle Scholar33. FIELDLOUBE JBSD: Observations concerning the diabetes mellitus associated with Werner's syndrome. Metabolism 9: 118, 1960. MedlineGoogle Scholar34. DAWEKEJAHNKEZIMMERMANN HKH: Untersuchungen des Kohlenhydrat-und Fettstoffwechsels beim Werner-syndrom. Deutsch. Arch. Klin. Med. 208: 553, 1963. MedlineGoogle Scholar35. STETTENBOXER DG: Studies in carbohydrate metabolism. The role of turnover of liver and carcass glycogen studies with the aid of deuterium. J. Biol. Chem. 155: 231, 1944. CrossrefGoogle Scholar36. LAWRENCE R: Lipodystrophy and hepatomegaly with diabetes, lipemia and other metabolic disturbances. Lancet 1: 724, 773, 1946. CrossrefMedlineGoogle Scholar37. HAMWIKRUGEREYMONTTGWINUPBYRON GJFAMGR: Lipoatrophic diabetes, in International Diabetes Federation, Fifth Congress, 1964, p. 73. Google Scholar38. BRINKFINDLAY AJCH: Werner's syndrome: ulcerating atrophodermia, cataract, and premature senility; report of a case. S. Afr. Med. J. 24: 318, 1950. MedlineGoogle Scholar39. COMMONSCALLAWAY RRCP: Adenomas of the adrenal cortex. Arch. Intern. Med. (Chicago) 81: 37, 1948. CrossrefGoogle Scholar40. PETERSONPIERCEWYNGAARDENBUNIMBRODIE RECEJBJJBB: The physiological disposition and metabolic fate of cortisone in man. J. Clin. Invest. 36: 1301, 1957. CrossrefMedlineGoogle Scholar41. PERLOFFPHELPS JKET: A review of Werner's syndrome with a report of the second autopsied case. Ann. Intern. Med. 48: 1205, 1958. LinkGoogle Scholar42. ROGERS AS: Werner's syndrome; report of a case with an unusual complication. J. Florida Med. Ass. 46: 436, 1959. MedlineGoogle Scholar43. BOYDGRANT MWAP: Werner's syndrome (progeria of the adult). Further pathological and biochemical observations. Brit. Med. J. 2: 920, 1959. CrossrefMedlineGoogle Scholar44. ELLISONPUGH DJDW: Werner's syndrome. Brit. Med. J. 2: 237, 1955. CrossrefMedlineGoogle Scholar45. STEINBERGSZEINBERGCOHEN AHABF: Amino-aciduria and hypermetabolism in progeria. Arch. Dis. Child. 32: 401, 1957. CrossrefMedlineGoogle Scholar46. ILLIS LA: Case of Werner's syndrome. Postgrad. Med. J. 38: 286, 1962. CrossrefMedlineGoogle Scholar47. DOAKEYRE PBKE: Werner's syndrome. New Zeal. Med. J. 59: 574, 1960. MedlineGoogle Scholar48. VALEROGELLEI AB: Retinitis pigmentosa, hypertension and uremia in Werner's syndrome. Report of a case with necropsy findings. Brit. Med. J. 2: 351, 1960. CrossrefMedlineGoogle Scholar49. LOUW AA: To Tilfaelde of Rothmund-Werner's sygdom. Nord. Med. 31: 2067, 1946. Google Scholar50. RUDE E: Werner's syndrome in three siblings. Acta Ophthal. (Københaven) 34: 255, 1956. CrossrefMedlineGoogle Scholar51. JACOBSONRIFKINZUCKER-FRANKLIN HGHD: Werner's syndrome: a clinical roentgen entity. Radiology 74: 373, 1960. CrossrefMedlineGoogle Scholar52. BOATWRIGHTWHEELERCAWLEY HCEEP: Werner's syndrome. Arch. Intern. Med. (Chicago) 90: 243, 1952. CrossrefGoogle Scholar53. FORCEPOWELL BRCP: Progeria in the adult (Werner's syndrome). Report of a case. U. S. Armed Forces Med. J. 1: 578, 1950. MedlineGoogle Scholar54. WORTZELNEWMANTOCZEK MHJHA: Werner's syndrome (a rare and most interesting genodermatosis). J. Newark Beth Israel Hosp. 15: 40, 1964. Google Scholar55. OSTENSJO B: Werner's syndrome-progeria genito-dystrophicum. Acta Dermatovener. (Stockholm) 33: 497, 1953. MedlineGoogle Scholar56. AGATSONGARTNER SAS: Precocious cataract and scleroderma. Arch. Ophthal. (Chicago) 21: 492, 1929. Google Scholar57. POMERANZ M: Werner's syndrome—a case report. Radiology 51: 521, 1948. CrossrefMedlineGoogle Scholar58. HERSTONEBOWER STJ: Werner's syndrome. Amer. J. Roentgen. 51: 639, 1944. Google Scholar59. ALBERTKOBILEIFERMANDERNER AJJI: Purification of pituitary gonadotropin from the urine of normal men. J. Clin. Endocr. 21: 1, 1961. CrossrefGoogle Scholar60. PETERSONKARRERGUERRA REASL: Evaluation of Silber-Porter procedure for determination of plasma hydrocortisone. Anal. Chem. 29: 144, 1957. CrossrefGoogle Scholar61. KLENDSHOJFELDSTEINSPRAGUE NCMA: Determination of 17-ketosteroids in urine. J. Clin. Endocr. 13: 922, 1953. CrossrefGoogle Scholar62. HENKEDOEJACOBSON WJRPME: A test of pituitary reserve utilizing intravenous SU-4885 with a new method for extraction of 11-desoxycorticosteroids. J. Clin. Endocr. 20: 1527, 1960. CrossrefMedlineGoogle Scholar63. BARKERHUMPHREYSOLEY SBMJMH: The clinical determination of protein bound iodine. J. Clin. Invest. 30: 55, 1951. CrossrefMedlineGoogle Scholar64. DOMINGUEZPEARSON JMOH: Immunologic measurement of growth hormone in human sera. J. Clin. Endocr. 22: 865, 1962. CrossrefGoogle Scholar65. BECKKOUMANSWINTERLINGSTEINDAUGHADAYKIPNIS PJHCAMFWHDM: Studies of insulin and growth hormone secretion in human obesity. J. Lab. Clin. Med. 64: 654, 1964. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Columbus, OhioFrom the Clinical Research Center and the Department of Medicine, Division of Endocrinology and Metabolism, Ohio State University Hospitals, Columbus, Ohio.This investigation was supported in part by Public Health Research Grant FR-34 (Clinical Research Center) and United States Public Health Service Training Grant TI AM 5118-08, U. S. Public Health Service, Bethesda, Md.Requests for reprints should be addressed to George J. Hamwi, M.D., F.A.C.P., Professor of Medicine, Director, Division of Endocrinology and Metabolism, Department of Medicine, The Ohio State University Hospitals, 410 West 10th Avenue, Columbus, Ohio 43210. 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