Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies
2004; Lippincott Williams & Wilkins; Volume: 10; Issue: 11 Linguagem: Inglês
10.1002/lt.20229
ISSN1527-6473
AutoresChristina Chan, Fran�ois Berthiaume, Bharath Nath, Arno W. Tilles, Mehmet Toner, Martin L. Yarmush,
Tópico(s)Organ Transplantation Techniques and Outcomes
ResumoThe severe donor liver shortage, high cost, and complexity of orthotopic liver transplantation have prompted the search for alternative treatment strategies for end-stage liver disease, which would require less donor material, be cheaper, and less invasive.Hepatic tissue engineering encompasses several approaches to develop adjunct internal liver support methods, such as hepatocyte transplantation and implantable hepatocyte-based devices, as well as temporary extracorporeal liver support techniques, such as bioartificial liver assist devices.Many tissue engineered liver support systems have passed the "proof of principle" test in preclinical and clinical studies; however, they have not yet been found sufficiently reliably effective for routine clinical use.In this review we describe, from an engineering perspective, the progress and remaining challenges that must be resolved in order to develop the next generation of implantable and extracorporeal devices for adjunct or temporary liver assist.(Liver
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